Arrhythmogenic right ventricular dysplasia/cardiomyopathy: a family affair.
نویسنده
چکیده
Has referral for genetic evaluation of inherited cardiomyopathies and arrhythmias become a routine part of your clinical practice yet? After several decades of molecular genetic research into the causes of inherited forms of heart disease, the field of cardiovascular genetics is rapidly growing. The pace of progress has accelerated even further in the setting of remarkable technologies that have lowered the costs and increased the speed with which gene sequencing can be performed. Two articles in the curent issue of Circulation point out both the benefits and challenges that are inherent in this evolving new era of genetic characterization as applied to arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), with particular attention to how this condition runs in families.1,2
منابع مشابه
MRI of arrhythmogenic right ventricular cardiomyopathy/dysplasia.
Magnetic Resonance Imaging (MRI) is currently considered as the noninvasive modality of choice for evaluation of patients with suspected Arrhythmogenic Right Ventricular Dysplasia (i.e., right ventricular dysplasia). As arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) it is included in the WHO classification of cardiomyopathies. It has the unique ability to provide tissue char...
متن کاملArrhythmogenic Ventricular Dysplasia/Cardiomyopathy: Insights from the Rationale of Disease Nomenclature and Clinical Perspectives
“Arrhythmogenic right ventricular dysplasia” (ARVD), a heart muscle disorder characterized by the presence of fibro-fatty tissue and ventricular electrical vulnerability related to sudden death, was first described in 1977 by a French team. Since then, other terms such as “arrhythmogenic right ventricular cardiomyopathy” (ARVC), “arrhythmogenic cardiomyopathy” (AC), “left-dominant arrhythmogeni...
متن کاملAdvances in Heart Failure Progress With Genetic Cardiomyopathies Screening, Counseling, and Testing in Dilated, Hypertrophic, and Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
This review focuses on the genetic cardiomyopathies: principally dilated cardiomyopathy, with salient features of hypertrophic cardiomyopathy and arrhythmogenic right ventricular dysplasia/cardiomyopathy, regarding genetic etiology, genetic testing, and genetic counseling. Enormous progress has recently been made in identifying genetic causes for each cardiomyopathy, and key phenotype and genot...
متن کاملProgress with genetic cardiomyopathies: screening, counseling, and testing in dilated, hypertrophic, and arrhythmogenic right ventricular dysplasia/cardiomyopathy.
This review focuses on the genetic cardiomyopathies: principally dilated cardiomyopathy, with salient features of hypertrophic cardiomyopathy and arrhythmogenic right ventricular dysplasia/cardiomyopathy, regarding genetic etiology, genetic testing, and genetic counseling. Enormous progress has recently been made in identifying genetic causes for each cardiomyopathy, and key phenotype and genot...
متن کاملPathologic evidence of extensive left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy.
Arrhythmogenic right ventricular cardiomyopathy (also known as arrhythmogenic right ventricular dysplasia) is characterized by adipose or fibroadipose tissue replacement of the right ventricular myocardium, whereas the left ventricle is substantively spared. Two cases of the disease with evidence of extensive left ventricular involvement at pathologic examination are described. Hearts from two ...
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عنوان ژورنال:
- Circulation
دوره 123 23 شماره
صفحات -
تاریخ انتشار 2011